Publications

Mariana Medina's Publications

Rapid on-chip apoptosis assay on human carcinoma cells based on annexin-V / quantum dot probes

Helena Montón, Mariana Medina-Sánchez, Joan Antoni Soler, Andrzej Chałupniak, Carme Nogués, Arben Merkoçi. Biosensors and Bioelectronics, 2017, Vol 94, pp 408-414
Despite all the efforts made over years to study the cancer expression and the metastasis event, there is not a clear understanding of its origins and effective treatment. Therefore, more specialized and rapid techniques are required for studying cell behaviour under different drug-based treatments. Here we present a quantum dot...

Water Activated Graphene Oxide Transfer Using Wax Printed Membranes for Fast Patterning of a Touch Sensitive Device

Luis Baptista-Pires, Carmen C. Mayorga-Martínez, Mariana Medina-Sánchez Helena Montón and Arben Merkoçi. ACS Nano, 2016, 10 (1), pp 853–860
We demonstrate a graphene oxide printing technology using wax printed membranes for the fast patterning and water activation transfer using pressure based mechanisms. The wax printed membranes have 50 μm resolution, longtime stability and infinite shaping capability. The use of these membranes complemented with the vacuum filtration...

Enhanced detection of quantum dots labelled protein by simultaneous bismuth electrodeposition into microfluidic channel

Mariana Medina-Sánchez, Sandrine Miserere, Miquell Cadevall and Arben Merkoçi. Volume 37, Issue 3 February 2016 Pages 432–437
In this study, we propose an electrochemical immunoassay into a disposable microfluidic platform, using quantum dots (QDs) as labels and their enhanced detection using bismuth as an alternative to mercury electrodes. CdSe@ZnS QDs were used as label to detect human IgG as a model protein and detected through highly sensitive stripping...

Eco-friendly electrochemical lab-on-paper for heavy metal detection

Mariana Medina-Sánchez, Miquel Cadevall, Josep Ros, Arben Merkoçi. Analytical and Bioanalytical Chemistry November 2015, Volume 407, Issue 28, pp 8445-8449
A disposable electrochemical lateral flow paper-based sensing device for heavy metal detection is proposed. The quantification of lead and cadmium in aqueous samples is demonstrated in a range from 10 to 100 ppb with a limit of detection of 7 and 11 ppb respectively. Moreover, the platform itself, which is made of paper, served...

Microfluidic platform for environmental contaminants sensing and degradation based on boron-doped diamond electrodes

Mariana Medina-Sánchez, Carmen C. Mayorga-Martinez, Takeshi Watanabe, Tribidasari A. Ivandini, Yuki Honda, Flavio Pino, Azuya Nakata, Akira Fujishima, Yasuaki Einaga, Arben Merkoçi.. Biosensors and Bioelectronics, Volume 75, 15 January 2016, Pages 365–374
We have developed a lab-on-a-chip (LOC) platform for electrochemical detection and degradation of the pesticide atrazine (Atz). It is based on boron-doped diamond (BDD) electrodes and a competitive magneto-enzyme immunoassay (EIA) that enables high sensitivity. To detect the enzymatic reaction, we employed a BDD electrode modified...

Antithyroid drug detection using an enzyme cascade blocking in a nanoparticle-based lab-on-a-chip system

Sevinc Kurbanoglu, Carmen C. Mayorga-Martinez, Mariana Medina-Sánchez, Lourdes Rivas, Sibel A. Ozkan, Arben Merkoçi.. Biosensors and Bioelectronics, 2015, 67, 670–676.
A methimazole (MT) biosensor based on a nanocomposite of magnetic nanoparticles (MNPs) functionalized with iridium oxide nanoparticles (IrOx NPs) and tyrosinase (Tyr) immobilized onto screen printed electrode (SPE) by using a permanent magnet is presented. This system is evaluated in batch mode via chelating copper at the active...

Improving sensitivity of gold nanoparticles-based lateral flow assays by using wax-printed pillars as delay barriers of microfluidics

Lourdes Rivas, Mariana Medina, Alfredo de la Escosura-Muñiz and Arben Merkoçi. Lab Chip, 2014, 14, 4406-4414
Although lateral flow assays (LFA) are currently being used in some point-of-care applications (POC) they cannot still be extended to a broader range of analytes for which higher sensitivities and lower detection limits are required. To overcome such drawbacks, we propose here a simple and facile alternative based on the use of delay...

An Inkjet-Printed Field-Effect Transistor for Label-Free Biosensing

Mariana Medina-Sanchez, Carme Martínez-Domingo, Eloi Ramon, Arben Merkoçi. . Advanced Functional Materials, 20 (40), 6291–6302. 2014
A flexible, biological field-effect transistor (BioFET) for use in biosensing is reported. The BioFET is based on an organic thin-film transistor (OTFT) fabricated mainly by inkjet printing and subsequently functionalized with antibodies for protein recognition. The BioFET is assessed for label-free detection of a model protein,...

Graphene/Silicon Heterojunction Schottky Diode for Vapors Sensing Using Impedance Spectroscopy

Ali Fattah, Saeid Khatami, Carmen C. Mayorga-Martinez, Mariana Medina-Sánchez, Luis Baptista-Pires and Arben Merkoçi. Small, 10 (20), 4193–4199. 2014
A graphene(G)/Silicon(Si) heterojunction Schottky diode and a simple method that evaluates its electrical response to different chemical vapors using electrochemical impedance spectroscopy (EIS) are implemented. To study the impedance response of the device of a given vapor, relative impedance change (RIC) as a function of the frequency...

Micromotor Enhanced Microarray Technology for Protein Detection

Eden Morales-Narváez, Maria Guix, Mariana Medina-Sánchez, Carmen C. Mayorga-Martinez, Arben Merkoçi. Small, Issue Small Small, 2014, 10, (13), 2542–2548
Microengines meet microarray technology. The transport of a target molecule toward a sensing surface can play a critical role in biodetection performance. The mixing induced by the motion of self-propelled micromotors can assist such transport and consequently enhance the performance of surface–based biosensing systems, particularly...